Evolution of Spreading Processes on Complex Networks

Most existing works on spreading processes assume that the propagating object, i.e., a virus or a piece of information, is transferred across the nodes without going through any modification. However, in real-life spreading processes, pathogens often evolve in response to changing environments and medical interventions, and information is often modified by individuals before being forwarded. In this paper, we investigate the evolution of spreading processes with the aim of i) revealing the role of evolution on the threshold, probability, and final size of epidemics; and ii) understanding the interplay between the structural properties of the network and the evolution process. In particular, we consider a SIR spreading process that starts with a single individual infected with strain-1 (that has transmissibility T_1). Once a susceptible individual receives the infection from the seed, the pathogen may evolve within that host with some probability. In particular, the pathogen may remain as strain-1 with probability μ_11 or mutate to strain-2 (that has transmissibility T_2) with probability μ_12=1-μ_11. If the pathogen remains as strain-1 (respectively, mutates to strain-2), then the host infects each of her susceptible neighbors in the subsequent stages independently with probability T_1 (respectively, T_2). Similarly, if any susceptible individual receives strain-2 at some point, the pathogen may remain as strain-2 with probability μ_22 or mutate to strain-1 with probability μ_21=1-μ_22.

We start by considering the case where coinfection is not possible, i.e., each infected host either carries strain-1 or strain-2, but not both. Existing research only explores the probability of epidemics, but lacks any insights on the expected epidemic size (denoted by S) or, more precisely, the expected fraction of individuals infected by each strain (denoted by S_1 and S_2, respectively). We present a theoretical framework that computes the expected epidemic size and the expected fraction of individuals infected by each strain for any choice of T_1, T_2, μ_11, μ_22, and any given degree distribution for the underlying contact network. Then, we explore the case where the emergence of coinfection is possible. In particular, a susceptible individual who gets infected with strain-1 and strain-2 simultaneously becomes coinfected, and starts to transmit the coinfection with transmissibility T_co. We show that coinfection gives rise to a rich set of dynamics: it can amplify or inhibit the spreading dynamics, and more remarkably lead the order of phase transition to change from second-order to first-order. We investigate the delicate interplay between the network structure, mutation schemes, and coinfection dynamics and reveal the cases where such interplay induces first-order phase transitions for the expected epidemic size.

Rashad Eletreby, Yong Zhuang and Osman Yagan
Tuesday, September 25, 2018 - 18:15 to 18:30


The official Hotel of the Conference is
Makedonia Palace.

Conference Organiser: NBEvents

The official travel agency of the Conference is: Air Maritime

Photo of Thessaloniki seafront courtesy of Juli Bellou
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